Pep Guardiola’s champions got their title defence underway in perfect fashion with a 5-0 thrashing of West Ham in east London, taking top stop in the table – a position they will not easily relinquish.
As for Tottenham, a late harry Kane double sealed a nervy 3-1 home victory over Aston Villa – but that win will already give Mauricio Pochettino’s men self-belief as they head into what will almost certainly be their toughest away test of the season.
Benjamin Mendy (knee) is out for City along with Leroy Sane, who will be missing for the next six or seven months with an ACL injury.
£60million summer signing Joao Cancelo could be considered for selection but is unlikely to start, while Fernandinho is lacking match fitness.
Heung-min Son is still suspended for Spurs which should see Lucas Moura start once again.
Dele Alli (thigh) and Juan Foyth (ankle) are both out, but Ben Davies is working on a return to full fitness.
Christian Eriksen came off the bench to change the game vs Aston Villa, but it remains to be seen whether the Danish playmaker – still seeking a move away from the club – will start, or again be used as an impact sub.
Possible Man City XI: Ederson, Walker, Stones, Laporte, Zinchenko, Rodri, De Buryne, David Silva, Bernardo Silva, Aguero, Sterling
Possible Tottenham XI: Lloris, Walker-Peters, Alderweireld, Sanchez, Rose, Ndombele, Winks, Sissoko, Lamela, Lucas, Kane
Prediction: Man City 2-1 Tottenham
Even the most optimistic Spurs fan will know that the likeliest result at the Etihad will be a home win.
Man City hit five past a new-look West Ham side without really breaking a sweat, but Harry Kane is fit and in form while the midfield battle between new signings Tanguy Ndombele and Rodri could be a classic.
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The match will be televised live on Sky Sports Premier League, Sky Sports Main Event and Sky Sports Ultra HD, and is available via NOW TV with a 10-month season ticket on offer for £199.
Sky Sports subscribers can stream the match online via SkyGo and the SkyGo app.
You can follow all the action and analysis on Standard Sport’s LIVE blog with Dan Kilpatrick at the Etihad Stadium.
City beat Tottenham twice in the League last season – 1-0 home and away – but Spurs got the better of Guardiola’s side in the Champions League quarter-finals en route to the final.